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What is Cocaine ?

Popular nicknames for cocaine include:

• Blow
• Coke
• Crack
• Rock
• 雪

How do people use cocaine?

People snort cocaine powder through the nose, or they rub it into their gums. Others dissolve the powder and inject it into the bloodstream. Some people inject a combination of cocaine and heroin, called a Speedball. 在线购买大众可卡因 .

Another popular method of use is to smoke cocaine that has been processed to make a rock crystal (also called “freebase cocaine”). The crystal is heated to produce vapors that are inhaled into the lungs.

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This form of cocaine is called Crack, which refers to the crackling sound of the rock as it’s heated. Some people also smoke Crack by sprinkling it on marijuana or tobacco, and smoke it like a cigarette.

People who use cocaine often take it in binges—taking the drug repeatedly within a short time, at increasingly higher doses—to maintain their high.

How does cocaine affect the brain?

Normally, dopamine recycles back into the cell that released it, shutting off the signal between nerve cells. However, cocaine prevents dopamine from being recycled, causing large amounts to build up in the space between two nerve cells, stopping their normal communication. This flood of dopamine in the brain’s reward circuit strongly reinforces drug-taking behaviors, because the reward circuit eventually adapts to the excess of dopamine caused by cocaine, and becomes less sensitive to it. As a result, people take stronger and more frequent doses in an attempt to feel the same high, and to obtain relief from withdrawal.

Short-Term Effects

Short-term health effects of cocaine include:

• extreme happiness and energy
• mental alertness
• hypersensitivity to sight, sound, and touch
• irritability
• paranoia—extreme and unreasonable distrust of others

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Some people find that cocaine helps them perform simple physical and mental tasks more quickly, although others experience the opposite effect. Large amounts of cocaine can lead to bizarre, unpredictable, and violent behavior.

Cocaine’s effects appear almost immediately and disappear within a few minutes to an hour. How long the effects last and how intense they are depend on the method of use. Injecting or smoking cocaine produces a quicker and stronger but shorter-lasting high than snorting. The high from snorting cocaine may last 15 to 30 minutes. The high from smoking may last 5 to 10 minutes.

What are the other health effects of cocaine use?

Other health effects of cocaine use include:

• constricted blood vessels
• dilated pupils
• nausea
• raised body temperature and blood pressure
• fast or irregular heartbeat
• tremors and muscle twitches
• restlessness

Long-Term Effects

Some long-term health effects of cocaine depend on the method of use and include the following:

• snorting: loss of smell, nosebleeds, frequent runny nose, and problems with swallowing
• smoking: cough, asthma, respiratory distress, and higher risk of infections like pneumonia
• consuming by mouth: severe bowel decay from reduced blood flow
• needle injection: higher risk for contracting HIV, hepatitis C, and other bloodborne diseases, skin or soft tissue infections, as well as scarring or collapsed veins

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However, even people involved with non-needle cocaine use place themselves at a risk for HIV because cocaine impairs judgment, which can lead to risky sexual behavior with infected partners (see “Cocaine, HIV, and Hepatitis” textbox).

Other long-term effects of cocaine use include being malnourished, because cocaine decreases appetite, and movement disorders, including Parkinson’s disease, which may occur after many years of use. In addition, people report irritability and restlessness from cocaine binges, and some also experience severe paranoia, in which they lose touch with reality and have auditory hallucinations—hearing noises that aren’t real. 在线购买大众可卡因 .

Can a person overdose on cocaine?

Yes, a person can overdose on cocaine. An overdose occurs when a person uses enough of a drug to produce serious adverse effects, life-threatening symptoms, or death. An overdose can be intentional or unintentional. Volkswagen Cocaine for Sale .

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Death from overdose can occur on the first use of cocaine or unexpectedly thereafter. Many people who use cocaine also drink alcohol at the same time, which is particularly risky and can lead to overdose. Others mix cocaine with heroin, another dangerous—and deadly—combination.

Some of the most frequent and severe health consequences of overdose are irregular heart rhythm, heart attacks, seizures, and strokes. Other symptoms of cocaine overdose include difficulty breathing, high blood pressure, high body temperature, hallucinations, and extreme agitation or anxiety. 在线购买大众可卡因 .

How can a cocaine overdose be treated?

There is no specific medication that can reverse a cocaine overdose. Management involves supportive care and depends on the symptoms present. For instance, because cocaine overdose often leads to a heart attack, stroke, or seizure, first responders and emergency room doctors try to treat the overdose by treating these conditions, with the intent of:

• restoring blood flow to the heart (heart attack)
• restoring oxygen-rich blood supply to the affected part of the brain (stroke)
• stopping the seizure

How does cocaine use lead to addiction?

As with other drugs, repeated use of cocaine can cause long-term changes in the brain’s reward circuit and other brain systems, which may lead to addiction. The reward circuit eventually adapts to the extra dopamine caused by the drug, becoming steadily less sensitive to it. As a result, people take stronger and more frequent doses to feel the same high they did initially and to obtain relief from withdrawal. 在线购买大众可卡因 .

Withdrawal symptoms include:

• depression
• fatigue
• increased appetite
• unpleasant dreams and insomnia
• slowed thinking

How can people get treatment for cocaine addiction?

Behavioral therapy may be used to treat cocaine addiction. Examples include:

• cognitive-behavioral therapy
• contingency management or motivational incentives—providing rewards to patients who remain substance free
• therapeutic communities—drug-free residences in which people in recovery from substance use disorders help each other to understand and change their behaviors
• community based recovery groups, such as 12-step programs

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While no government-approved medicines are currently available to treat cocaine addiction, researchers are testing some treatments that have been used to treat other disorders, including:

• disulfiram (used to treat alcoholism)
• modanifil (used to treat narcolepsy—a disorder characterized by uncontrollable episodes of deep sleep)
• lorcaserin (used to treat obesity)
• buprenorphine (used to treat opioid addiction)

Learn More

For more information about cocaine, visit our:

• Cocaine webpage
• Commonly Used Drug Charts webpage
• NIDA for Teens Drug Facts on Cocaine – Offers resources for teens and teen influencers. Get the latest on how drugs affect the brain and body. Features videos, games, blog posts, and more!
• Easy-to-Read Drug Facts on Cocaine (Coke, Crack)  – Has pictures and videos to help readers understand the text. The website also can read each page out loud.

For more information about drug use and HIV/AIDS, visit our webpage, Drug Use and Viral Infections (HIV, Hepatitis).

This publication is available for your use and may be reproduced in its entirety without permission from NIDA. Citation of the source is appreciated, using the following language: Source: National Institute on Drug Abuse; National Institutes of Health; U.S. Department of Health and Human Services. 在线购买大众可卡因 .